Preliminary work towards a CRISPR based gene drive involving Sox9 in Mus musculus

Mus musculus

House mouse

Intended use

‘eradicating invasive rodent populations on islands’ to address impacts on biodiversity

Readiness of Technology

4a - Active research on gene drive construction

Institution

Probably University of Adelaide

Publications

Campbell et al., 2019

Authors name for system

‘CRISPR/Cas9 and CRISPR/Cpf1 gene drives with Sox9 and Y-shredder’

Field(s) of application

Conservation

Additional notes

It is uncertain how far development of this gene drive has progressed. Campbell et al. state that 'development of CRISPR/Cpf1 gene drives and incorporating Sox9... [is] underway' but no further information has been published despite substantial funding.

Description of system

CRISPR based gene drive involving Sox9 – probably a homing CRISPR drive with Sox9 cargo

For specialists

Research in target organism

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Research in model organism

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Intended for release

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Intended direct effects

Population suppression/eradication