Split homing CRISPR for population suppression in Anopheles stephensi - Pirbright Institute

Intended use

reduction of transmission of malaria pathogen by this vector (to reduce morbidity and mortality from malaria in Southern Asia, the Arabian Peninsula and East Africa)

Readiness of Technology

5 - Limited proof of concept in laboratory

Project leader

Anderson MAE

Institution

Pirbright Institute, UK

Project leader

Alphey L

Institution

Pirbright Institute, UK

Publications

Larrosa-Godall et al., 2025

Authors name for system

split drive targeting dsx

Class of Technology

Split homing gene drive

Field(s) of application

Vector control

Description of system

Split homing CRISPR targeting doublesex gene

For specialists

Research in target organism

✖

Research in model organism

✖

Intended for release

✖

Intended direct effects

Population suppression/eradication