Homing CRISPR gene drive in Mus musculus - University of California San Diego

House mouse

Intended use

Initial aims: 1) using gene drive technology to create lab mouse strains carrying multiple modifications (with otherwise impractical genotypes) for laboratory studies 2) finding a way to eliminate invasive rodent species or addressing rodent-borne disease

Readiness of Technology

5 - Limited proof of concept in laboratory

Project leader

Cooper KL

Institution

University of California San Diego, USA

Publications

Grunwald et al., 2019

Weitzel, et al. 2021

Grunwald et al. 2022

Authors name for system

CRISPR-Cas9 mediated gene drive

Class of Technology

Homing gene drive

Field(s) of application

General research and development

Description of system

Homing CRISPR

For specialists

Research in target organism

✖

Research in model organism

✖

Intended for release

✖

Intended direct effects

NA - Proof of concept