Preliminary work towards a homing CRISPR gene drive in Scolytinae subfamily - Peking University

Bark beetles

Intended use

Reduction of damage to timber crops caused by this species

Readiness of Technology

2a - Gene drive proposed with supporting theoretical work

Project leader

Champer J

Institution

Peking University

Publications

Authors name for system

NA – preliminary theoretical study

Class of Technology

Homing gene drive

Field(s) of application

Agriculture

Additional notes

Note that Li, Aidlin Harari, et al. (2020) also imply these species could be a target.

Description of system

Homing CRISPR

Description

Homing CRISPR gene drive targeting a haplo-sufficient female fertility gene.

Notes on readiness of technology

Modelling study suggests feasibility of targeting haplodiploid species with a suppression drive targeting female fertility.

This species is given as an example of a possible target amongst others.

Note that Li, Aidlin Harari, et al. 2020 also imply these species could be a target.

Phenotype

Female infertility in homozygotes.

Research in target organism

✖

Research in model organism

✖

Intended for release

✖

Intended direct effects

Population suppression/eradication