Preliminary work towards a homing CRISPR gene drive with ‘Y shredder’ cargo in Mus musculus - University of Adelaide

Mus musculus

House mouse

Intended use

‘Suppression or eradication’ of rodent populations to reduce impacts on biodiversity and agriculture

Readiness of Technology

2a - Gene drive proposed with supporting theoretical work

Project leader

Ross JV

Institution

University of Adelaide, Australia

Publications

Prowse et al., 2019

Campbell et al., 2019

Authors name for system

Y chromosome shredding gene drive (Campbell et al., 2019); ‘Y-Chromosome deletion using Orthogonal Programmable Endonucleases (Y-CHOPE)’ (Prowse et al., 2019)

Class of Technology

Homing gene drive

Field(s) of application

Conservation

Additional notes

It is uncertain how far development of this gene drive has progressed. Campbell et al. state that 'development of CRISPR/Cpf1 gene drives and incorporating... Y-shredder [is] underway.' No further information has been published

Description of system

Homing CRISPR (with ‘Y shredder’ cargo)

For specialists

Research in target organism

✖

Research in model organism

✖

Intended for release

✖

Intended direct effects

Population suppression/eradication