Preliminary work towards a homing CRISPR gene drive in Rattus rattus - University of Adelaide

Common rat or black rat

Intended use

‘eradication of alien rodents on islands’ to address impacts on bio-diversity. The impacts of rodents on agriculture are also noted as a driver.

Readiness of Technology

2a - Gene drive proposed with supporting theoretical work

Project leader

Thomas PQ

Institution

University of Adelaide, Australia

Publications

Authors name for system

‘CRISPR gene drive’; Two variants modelled: ‘Homozygotic embryonic nonviability’ ; ‘Homozygotic XX sterility’

Class of Technology

Homing gene drive

Sex ratio distorter

Field(s) of application

Agriculture

Conservation

Description of system

Homing CRISPR – two variants modelled

Research in target organism

✖

Research in model organism

✖

Intended for release

✖

Intended direct effects

Population suppression/eradication