Preliminary work towards homing CRISPR gene drives in Rattus Norvegicus - University of Adelaide

Brown rat

Intended use

'landscape-scale suppression of rodent populations' with use in 'eradication efforts on large islands' noted as a possibility

Readiness of Technology

2a - Gene drive proposed with supporting theoretical work

Project leader

Thomas PQ

Institution

University of Adelaide, Australia

Publications

Authors name for system

'Standard homing drives embedded in haplosufficient fertility or viability genes'

Class of Technology

Homing gene drive

Field(s) of application

Conservation

Additional notes

The paper also mentions Rattus species in general as a target.

Description of system

Homing CRISPR - three variants modelled targeting: (i) a female fertility gene, (ii) a male fertility gene, and (iii) a viability gene

Research in target organism

✖

Research in model organism

✖

Intended for release

✖

Intended direct effects

Population suppression/eradication