Gene Drive Projects
Select one or more options to filter by taxonomic groups.
Animalia
Mollusca (incl. snails)
Gastropoda (slugs and snails)
Hygrophila (freshwater snails)
Readiness of Technology
3 - Preliminary laboratory work publishedPublications
Intended use
To modify snail populations to increase their immunity to schistosome infection, thereby disrupting the schistosome lifecycle and reducing transmission to humans.
Type of system
Not specified but cites examples of homing CRISPR
Readiness of Technology
2a - Gene drive proposed with supporting theoretical workPublications
Intended use
To modify snail populations to increase their immunity to schistosome infection, thereby disrupting the schistosome lifecycle and reducing transmission to humans
Type of system
Homing CRISPR
No common name
Readiness of Technology
2b - Gene drive proposed with preliminary laboratory work fundedPublications
Intended use
Modification of natural snail populations to reduce schistosomiasis prevalence and transmission
Type of system
Several approaches proposed
Nematoda (roundworms)
Chromadorea (class of roundworms)
Rhabditida (order of roundworms)
Readiness of Technology
4a - Active research on gene drive constructionPublications
Intended use
to ‘test and optimize daisychain, daisyfield, and daisy quorum drives—including for daisy restoration—in fast-reproducing laboratory populations of worms…‘
Type of system
Daisy-chain drive, daisyfield drive, daisy quorum drive
Platyhelminthes (flatworms)
Trematoda (flukes)
Diplostomida (order of flukes)
Blood fluke
Readiness of Technology
4a - Active research on gene drive constructionPublications
Intended use
To suppress schistosome parasites to thereby reduce human morbidity and mortality from schistomiasis
Type of system
Z linked W-shredder, with variable parameters (as described by Holman, 2019)
Fungi
Ascomycota (sac fungi)
Saccharomycetes (budding yeasts)
Saccharomycetales (budding yeasts)
Readiness of Technology
6 - Laboratory proof of conceptPublications
Intended use
To create single and double deletion mutants in this species for laboratory studies.
Type of system
Split homing CRISPR
brewer’s or baker’s yeast
Readiness of Technology
6 - Laboratory proof of conceptPublications
Intended use
Proof of principle of population modification via a split homing gene drive in this model organism.
Type of system
Split homing CRISPR
brewer’s or baker’s yeast
Readiness of Technology
4a - Active research on gene drive constructionPublications
Intended use
To study gene drives over many generations to understand the emergence of resistance.
Type of system
Probably homing CRISPR (as team had used this technology in other work)
brewer’s or baker’s yeast
Readiness of Technology
6 - Laboratory proof of conceptPublications
Intended use
To test various methods to modulate gene drive activity, e.g. Cas9 expression level (Roggenkamp et al. 2018) and Cas9 nuclear localisation (Goeckel et al. 2019).
Type of system
Split homing CRISPR
brewer’s or baker’s yeast
Readiness of Technology
6 - Laboratory proof of conceptPublications
Intended use
To test a split gene drive system to simultaneously propagate gene drives at three different loci
Type of system
Multi-locus split homing CRISPR