Gene Drive Projects
Select one or more options to filter by taxonomic groups.
Animalia
Chordata (incl. vertebrates e.g. mammals and birds)
Mammalia (mammals)
Rodentia (rodents)
Muridae (mice, rats, and gerbils)
Mus (mice)
House mouse
Readiness of Technology
4a - Active research on gene drive constructionPublications
Intended use
‘eradicating mice from islands’ or at continental scale, presumably in Australia, to address their impacts on biodiversity
Type of system
Homing CRISPR (targeting ‘haplosufficient female fertility gene’)
House mouse
Readiness of Technology
3 - Preliminary laboratory work publishedPublications
Intended use
‘Suppressing’ invasive rodents on islands to reduce impacts on biodiversity, agriculture and human health
Type of system
Homing CRISPR (targeting locally fixed alleles of female fertility genes)
House mouse
Readiness of Technology
2a - Gene drive proposed with supporting theoretical workPublications
Intended use
‘eradication of alien rodents on islands’ to address impacts on biodiversity; The impacts of rodents on agriculture are also noted as a driver
Type of system
Homing CRISPR – four designs modelled
House mouse
Readiness of Technology
4a - Active research on gene drive constructionPublications
Intended use
‘eradicating invasive rodent populations on islands’ to address impacts on biodiversity
Type of system
CRISPR based gene drive involving Sox9 – probably a homing CRISPR drive with Sox9 cargo
House mouse
Readiness of Technology
2a - Gene drive proposed with supporting theoretical workPublications
Intended use
Eradicating invasive mouse populations on islands to address biodiversity impacts - with the Southeast Farallon island used as a case study
Type of system
Homing CRISPR (with Sox9 cargo)
House mouse
Readiness of Technology
2a - Gene drive proposed with supporting theoretical workPublications
Intended use
‘eradication of alien rodents on islands’ to address impacts on biodiversity; Aim ultimately is also to address impacts of alien rodents (esp. mice and rabbits) on agricultural production
Type of system
Homing CRISPR - four designs modelled
House mouse
Readiness of Technology
2a - Gene drive proposed with supporting theoretical workPublications
Intended use
‘Suppression or eradication’ of rodent populations to reduce impacts on biodiversity and agriculture
Type of system
Homing CRISPR (with ‘Y shredder’ cargo)
House mouse
Readiness of Technology
2b - Gene drive proposed with preliminary laboratory work fundedPublications
Intended use
‘eradication of alien rodents on islands’ to address impacts on bio-diversity; The impacts of rodents on agriculture are also noted as a driver
Type of system
Homing CRISPR – four designs modelled
House mouse
Readiness of Technology
4a - Active research on gene drive constructionPublications
Intended use
To demonstrate feasibility of a gene drive rendering wild deer immune to chronic wasting disease [by spreading PRNP null alleles]
Type of system
Homing CRISPR
House mouse
Readiness of Technology
5 - Limited proof of concept in laboratoryIntended use
To explore the potential of an engineered form of the T-haplotype for ‘mouse population suppression or even eradication on islands’
Type of system
Split drive: a) T-haplotype element with gRNA cargo targeting ‘haplosufficient female fertility gene’ (Prl); b) Cas9 expressed separately (in male germline)