Gene Drive Projects
Select one or more options to filter by taxonomic groups.
Animalia
Chordata (incl. vertebrates e.g. mammals and birds)
Mammalia (mammals)
Rodentia (rodents)
Muridae (mice, rats, and gerbils)
Rattus (rats)
Polynesian rat
Readiness of Technology
1 - Gene drive proposedPublications
Intended use
To eradicate invasive populations in New Zealand to prevent predation of native species.
Type of system
Homing CRISPR
Polynesian rat
Readiness of Technology
1 - Gene drive proposedPublications
Intended use
To control/ eliminate invasive populations on islands
Type of system
Not specified – t-haplotype and homing CRISPR both mentioned
Brown rat
Readiness of Technology
2a - Gene drive proposed with supporting theoretical workPublications
Intended use
Eradicating invasive rat populations on islands to address their impacts on biodiversity
Type of system
Homing CRISPR (targeting ‘haplosufficient female fertility gene’ or ‘haplosufficient zygote viability gene’) and ‘Y-shredder’ (located on X-chromosome)
Brown rat
Readiness of Technology
1 - Gene drive proposedPublications
Intended use
To eradicate invasive populations in New Zealand
Type of system
Homing CRISPR
Brown rat
Readiness of Technology
1 - Gene drive proposedIntended use
‘to curb pest rodent populations’
Type of system
Homing CRISPR (targeting ‘haplosufficient female fertility gene’)
Brown rat
Readiness of Technology
1 - Gene drive proposedPublications
Intended use
To control/ eliminate invasive populations on islands
Type of system
Not specified – t-haplotype and homing CRISPR both mentioned
Brown rat
Readiness of Technology
1 - Gene drive proposedPublications
Intended use
To eradicate invasive populations on islands
Type of system
T-haplotype sex ratio distorter (carrying SRY cargo)
Brown rat
Readiness of Technology
2a - Gene drive proposed with supporting theoretical workPublications
Intended use
'landscape-scale suppression of rodent populations' with use in 'eradication efforts on large islands' noted as a possibility
Type of system
Homing CRISPR - three variants modelled targeting: (i) a female fertility gene, (ii) a male fertility gene, and (iii) a viability gene
Brown rat
Publications
Intended use
'landscape-scale suppression of rodent populations' with use in 'eradication efforts on large islands' noted as a possibility
Type of system
Homing CRISPR 'rescue' embedded in haplolethal gene that also targets independent gene - three variants modelled targeting: (i) a female fertility gene, (ii) a male fertility gene, and (iii) a viability gene
Brown rat
Readiness of Technology
4a - Active research on gene drive constructionPublications
Intended use
The production of complex strains harboring multiple humanizing genes
Type of system
Split gene drive system - multiple configurations tested