Gene Drive Projects
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Animalia
Chordata (incl. vertebrates e.g. mammals and birds)
Mammalia (mammals)
Rodentia (rodents)
Muridae (mice, rats, and gerbils)
Mus (mice)
House mouse
Readiness of Technology
2a - Gene drive proposed with supporting theoretical workPublications
Intended use
‘eradication of alien rodents on islands’ to address impacts on biodiversity; Aim ultimately is also to address impacts of alien rodents (esp. mice and rabbits) on agricultural production
Type of system
Homing CRISPR - four designs modelled
House mouse
Readiness of Technology
2a - Gene drive proposed with supporting theoretical workPublications
Intended use
‘Suppression or eradication’ of rodent populations to reduce impacts on biodiversity and agriculture
Type of system
Homing CRISPR (with ‘Y shredder’ cargo)
House mouse
Readiness of Technology
2b - Gene drive proposed with preliminary laboratory work fundedPublications
Intended use
‘eradication of alien rodents on islands’ to address impacts on bio-diversity; The impacts of rodents on agriculture are also noted as a driver
Type of system
Homing CRISPR – four designs modelled
House mouse
Readiness of Technology
4a - Active research on gene drive constructionPublications
Intended use
To demonstrate feasibility of a gene drive rendering wild deer immune to chronic wasting disease [by spreading PRNP null alleles]
Type of system
Homing CRISPR
House mouse
Readiness of Technology
5 - Limited proof of concept in laboratoryPublications
Intended use
To explore the potential of an engineered form of the T-haplotype for ‘mouse population suppression or even eradication on islands’
Type of system
Split drive: a) T-haplotype element with gRNA cargo targeting ‘haplosufficient female fertility gene’ (Prl); b) Cas9 expressed separately (in male germline)
House mouse
Readiness of Technology
4a - Active research on gene drive constructionPublications
Intended use
Eradicating invasive populations on islands to address biodiversity impacts
Type of system
T-haplotype sex ratio distorter (carrying Sry cargo)
House mouse
Readiness of Technology
2a - Gene drive proposed with supporting theoretical workPublications
Intended use
Eradicating invasive populations on islands to address biodiversity impacts
Type of system
T-haplotype sex ratio distorter (carrying Sry cargo)
House mouse
Readiness of Technology
2a - Gene drive proposed with supporting theoretical workPublications
Intended use
Eradicating invasive populations on islands to address biodiversity impacts
Type of system
T-haplotype sex ratio distorter (carrying Sry cargo)
House mouse
Readiness of Technology
4a - Active research on gene drive constructionPublications
Intended use
‘eradicating mice from islands’ or at continental scale [presumably Australia] to address their impacts on biodiversity
Type of system
CRISPR based X-shredder gene drive (‘driving Y’)
House mouse
Readiness of Technology
4a - Active research on gene drive constructionPublications
Intended use
The production of complex strains harboring multiple humanizing genes
Type of system
Split gene drive system - multiple configurations tested