Gene Drive Projects
Select one or more options to filter by taxonomic groups.
Animalia
Chordata (incl. vertebrates e.g. mammals and birds)
Mammalia (mammals)
Rodentia (rodents)
Muridae (mice, rats, and gerbils)
Rattus (rats)
Common rat or black rat
Readiness of Technology
2a - Gene drive proposed with supporting theoretical workPublications
Intended use
‘eradication of alien rodents on islands’ to address impacts on bio-diversity. The impacts of rodents on agriculture are also noted as a driver.
Type of system
Homing CRISPR – two variants modelled
Common rat or black rat
Readiness of Technology
2a - Gene drive proposed with supporting theoretical workPublications
Intended use
Eradicating invasive rat populations on islands to address their impacts on biodiversity
Type of system
Homing CRISPR (targeting ‘haplosufficient female fertility gene’ or ‘haplosufficient zygote viability gene’) and ‘Y-shredder’ (located on X-chromosome)
Common rat or black rat
Readiness of Technology
2a - Gene drive proposed with supporting theoretical workPublications
Intended use
Eradication of this species at continental scale, presumably in Australia, to address impacts on biodiversity
Type of system
Homing CRISPR or ‘Y-linked X shredder’- Y-chromosome-linked X-shredder
Common rat or black rat
Readiness of Technology
1 - Gene drive proposedPublications
Intended use
To eradicate invasive populations in New Zealand
Type of system
Homing CRISPR
Common rat or black rat
Readiness of Technology
1 - Gene drive proposedPublications
Intended use
To control or eradicate invasive populations in Australia
Type of system
Homing CRISPR
Common rat or black rat
Readiness of Technology
1 - Gene drive proposedPublications
Intended use
To control/ eliminate invasive populations on islands
Type of system
Not specified – t-haplotype and homing CRISPR both mentioned
Common rat or black rat
Readiness of Technology
1 - Gene drive proposedPublications
Intended use
To eradicate invasive populations on islands
Type of system
T-haplotype sex ratio distorter (carrying SRY cargo)
Common rat or black rat
Readiness of Technology
1 - Gene drive proposedPublications
Intended use
To eradicate invasive populations in New Zealand
Type of system
Homing CRISPR
Sciuridae (squirrels)
Sciurus (incl. most bushy tailed squirrels)
Grey squirrel
Readiness of Technology
2a - Gene drive proposed with supporting theoretical workPublications
Intended use
To ‘control a targeted grey squirrel population’ to reduce impacts on biodiversity and damage to property in the UK (where it is invasive)
Type of system
Homing CRISPR + Cleave and Rescue [Toxin Antidote] CRISPR combination, with ‘daisy-field’
Grey squirrel
Publications
Intended use
To control populations of this species to reduce impacts on biodiversity and forestry in the UK (where it is invasive)
Type of system
NA- Stakeholder engagement study