Gene Drive Projects
Select one or more options to filter by taxonomic groups.
Animalia
Arthropoda (incl. insects and spiders)
Insecta (insects)
Diptera (true flies)
Culicidae (mosquitoes)
Anopheles (marsh mosquitoes)
African malaria mosquito
Readiness of Technology
5 - Limited proof of concept in laboratoryPublications
Intended use
Reduction of transmission of malaria pathogen by this vector (to reduce morbidity and mortality from malaria in Sub-Saharan Africa)
Type of system
Homing gene drive targeting miR184
African malaria mosquito
Readiness of Technology
5 - Limited proof of concept in laboratoryPublications
Intended use
Reduction of transmission of malaria pathogen by this vector (to reduce morbidity and mortality from malaria in Sub-Saharan Africa)
Type of system
Split homing CRISPR variant causing a modification of the linked FREP1 gene
African malaria mosquito
Readiness of Technology
6 - Laboratory proof of conceptPublications
Intended use
Reduction of transmission of malaria pathogen by this vector (to reduce morbidity and mortality from malaria in Sub-Saharan Africa)
Type of system
Homing gene drive targeting doublesex gene - male drive female sterile variant
African malaria mosquito
Readiness of Technology
6 - Laboratory proof of conceptPublications
Intended use
Reduction of transmission of malaria pathogen by this vector (to reduce morbidity and mortality from malaria in Sub-Saharan Africa)
Type of system
Homing gene drive targeting doublesex gene - male drive female sterile variant - with autosomal X shredder
African malaria mosquito
Publications
Intended use
Reduction of transmission of malaria pathogen by this vector (to reduce morbidity and mortality from malaria in Sub-Saharan Africa)
Type of system
Homing CRISPR variant - 'Integral gene drive' targeting nanos
African malaria mosquito
Readiness of Technology
5 - Limited proof of concept in laboratoryPublications
Intended use
Reduction of transmission of malaria pathogen by this vector (to reduce morbidity and mortality from malaria in Sub-Saharan Africa)
Type of system
Homing CRISPR targeting the Agcd (cardinal) gene with compound cargo constructs. Two different strains generated named AgTp24 and AgTp43.
common malaria mosquito
Readiness of Technology
3 - Preliminary laboratory work publishedPublications
Intended use
Reduction of transmission of pathogens (including malaria and lymphatic filariasis) by these vectors in North America
Type of system
Homing CRISPR (probably)
Asian malaria mosquito
Readiness of Technology
5 - Limited proof of concept in laboratoryPublications
Intended use
Reduction of transmission of malaria pathogen by this vector (to reduce morbidity and mortality from malaria in India and surrounding regions)
Type of system
Homing CRISPR
Asian malaria mosquito
Readiness of Technology
5 - Limited proof of concept in laboratoryPublications
Intended use
Reduction of transmission of malaria pathogen by this vector
Type of system
Homing CRISPR
Asian malaria mosquito
Readiness of Technology
5 - Limited proof of concept in laboratoryPublications
Intended use
reduction of transmission of malaria pathogen by this vector (to reduce morbidity and mortality from malaria in Southern Asia, the Arabian Peninsula and East Africa)
Type of system
Split homing CRISPR targeting doublesex gene