Gene Drive Projects
Select one or more options to filter by taxonomic groups.
Animalia
Arthropoda (incl. insects and spiders)
Insecta (insects)
Diptera (true flies)
Culicidae (mosquitoes)
Anopheles (marsh mosquitoes)
African malaria mosquito
Readiness of Technology
5 - Limited proof of concept in laboratoryPublications
Intended use
Reduction of transmission of malaria pathogen by this vector (to reduce morbidity and mortality from malaria in Sub-Saharan Africa)
Type of system
Split homing CRISPR variant
African malaria mosquito
Readiness of Technology
5 - Limited proof of concept in laboratoryPublications
Intended use
Reduction of transmission of malaria pathogen by this vector
Type of system
Split homing CRISPR variant
African malaria mosquito
Readiness of Technology
5 - Limited proof of concept in laboratoryPublications
Intended use
Reduction of transmission of malaria pathogen by this vector (to reduce morbidity and mortality from malaria in Sub-Saharan Africa)
Type of system
Homing CRISPR variant
African malaria mosquito
Readiness of Technology
4b - research on gene drive construction has taken place but evidence so far shows this approach doesn't workPublications
Intended use
Presumably reduction of transmission of malaria by this vector.
Type of system
An attempt to construct a sex ratio distorter based on 'X-poisoning, which eliminates females inheriting disrupted X-chromosomes'. Instead the system appears to function via 'X-shredding,' , i.e. the elimination of X-bearing sperm.
African malaria mosquito
Readiness of Technology
6 - Laboratory proof of conceptPublications
Intended use
Potential to inform development of similar systems ' in other pest species where the female sex is not directly causing harm...'
Type of system
An autosomal sex ratio distorter employing CRISPR-cas9 to target 'Y-chromosome specific sequences'
African malaria mosquito
Readiness of Technology
4a - Active research on gene drive constructionPublications
Intended use
Reduction of transmission of malaria pathogen by this vector (to reduce morbidity and mortality from malaria in Sub-Saharan Africa)
Type of system
Homing CRISPR gene drive variant
African malaria mosquito
Readiness of Technology
5 - Limited proof of concept in laboratoryPublications
Intended use
Reduction of transmission of malaria pathogen by this vector (to reduce morbidity and mortality from malaria in Sub-Saharan Africa)
Type of system
Homing gene drive targeting miR184
African malaria mosquito
Readiness of Technology
5 - Limited proof of concept in laboratoryPublications
Intended use
Reduction of transmission of malaria pathogen by this vector (to reduce morbidity and mortality from malaria in Sub-Saharan Africa)
Type of system
Split homing CRISPR variant causing a modification of the linked FREP1 gene
African malaria mosquito
Readiness of Technology
6 - Laboratory proof of conceptPublications
Intended use
Reduction of transmission of malaria pathogen by this vector (to reduce morbidity and mortality from malaria in Sub-Saharan Africa)
Type of system
Homing gene drive targeting doublesex gene - male drive female sterile variant
African malaria mosquito
Readiness of Technology
6 - Laboratory proof of conceptPublications
Intended use
Reduction of transmission of malaria pathogen by this vector (to reduce morbidity and mortality from malaria in Sub-Saharan Africa)
Type of system
Homing gene drive targeting doublesex gene - male drive female sterile variant - with autosomal X shredder