Gene Drive Projects
Select one or more options to filter by taxonomic groups.
Animalia
Arthropoda (incl. insects and spiders)
Insecta (insects)
Diptera (true flies)
Culicidae (mosquitoes)
Anopheles (marsh mosquitoes)
Asian malaria mosquito
Readiness of Technology
5 - Limited proof of concept in laboratoryPublications
Intended use
reduction of transmission of malaria pathogen by this vector (to reduce morbidity and mortality from malaria in Southern Asia, the Arabian Peninsula and East Africa)
Type of system
Homing gene drive targeting doublesex gene
Asian malaria mosquito
Readiness of Technology
5 - Limited proof of concept in laboratoryPublications
Intended use
The aim is to 'pave the way for future gene drive designs with multiple sgRNAs expressed by multiple RNA Pol III promoters to mitigate resistance.'
Type of system
Split homing CRISPR targeting cardinal gene - four variants with different promoters for the sgRNA
Culex (typical mosquitoes)
Southern house mosquito
Readiness of Technology
5 - Limited proof of concept in laboratoryPublications
Intended use
Reduction of transmission of vector borne diseases in humans, mammals and birds (e.g. avian malaria)
Type of system
Split homing CRISPR
Southern house mosquito
Readiness of Technology
3 - Preliminary laboratory work publishedPublications
Intended use
Reduction of transmission of vector borne diseases in humans, mammals and birds (e.g. avian malaria)
Type of system
Unspecified - CRISPR based
Drosophilidae (fruit flies)
Drosophila (fruit flies)
Spotted winged drosophila
Readiness of Technology
5 - Limited proof of concept in laboratoryPublications
Intended use
Reduction of damage to soft fruit crops (e.g. cherries) caused by this species
Type of system
Medea gene drive
Spotted winged drosophila
Readiness of Technology
3 - Preliminary laboratory work publishedPublications
Intended use
Reduction of damage to soft fruit crops (e.g. cherries) caused by this species
Type of system
Propose homing CRISPR
Spotted winged drosophila
Readiness of Technology
5 - Limited proof of concept in laboratoryPublications
Intended use
Reduction of damage to soft fruit crops (e.g. cherries) caused by this species
Type of system
Split homing CRISPR
Spotted winged drosophila
Readiness of Technology
1 - Gene drive proposedPublications
Intended use
Reduction of economic costs caused by consumption of fruit crops by this species.
Type of system
NA- Stakeholder engagement study
Spotted winged drosophila
Readiness of Technology
5 - Limited proof of concept in laboratoryPublications
Intended use
Reduction of damage to soft fruit crops (e.g. cherries) caused by this species
Type of system
Homing gene drive targeting Tyrosine decaroxylase 2 (Tdc2) - a recessive female fertility gene
Spotted winged drosophila
Readiness of Technology
5 - Limited proof of concept in laboratoryPublications
Intended use
Reduction of damage to soft fruit crops (e.g. cherries) caused by this species
Type of system
Homing CRIPSR gene drive targeting transformer gene